Cell BiologybioRxiv
Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells
L. Sui, D. M. Egli, Y. Xin…·R. Goland
The paper investigates how limitations in S-phase progression affect pancreatic endocrine differentiation and graft growth, finding that impaired DNA replication enhances differentiation and prevents cystic growth.
DOI 10.1172/jci.insight.141553