Synergistic Modulation of Macrophages by Methotrexate and RELA siRNA Folate-Liposome: A Precision Therapy to Prevent Joint Degradation in Collagen-Induced Arthritic Rats
This study develops a folate-liposomal delivery system combining Methotrexate and RELA siRNA to target macrophage polarization in RA, reducing inflammation and joint damage in a rat model.
bioRxiv · Jan 3, 2024 · PreprintPharmacology & Toxicology