Author

D. C. Ko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

L. Wang· 4 shared A. L. Antonia· 3 shared B. H. Schott· 2 shared A. T. Martin· 1 shared B. E. Fee· 1 shared C. E. Anderson· 1 shared D. N. Cook· 1 shared D. Wang· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersMicrobiology

L. Wang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Integration of the Salmonella Typhimurium methylome and transcriptome reveals DNA methylation and transcriptional regulation are largely decoupled under virulence-related conditions

J. Bourgeois, C. E. Anderson, L. Wang, J. L. Modliszewski, W. Chen, B. H. Schott, N. Devos, D. C. Ko

This study integrates DNA methylome and transcriptome data from Salmonella Typhimurium under different conditions, finding that DNA methylation is largely static and only rarely correlates with gene expression changes.

bioRxiv · Nov 11, 2021Microbiology

Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor

A. L. Antonia, A. T. Martin, L. Wang, D. C. Ko

This study identifies variation in Leishmania chemokine suppression linked to GP63 diversification, showing how parasite genetic differences affect immune response outcomes.

bioRxiv · Feb 1, 2021 · PreprintMicrobiology

Th17 immunity in the colon is controlled by two novel subsets of colon-specific mononuclear phagocytes

H.-I. Huang, M. L. Jewell, N. Youssef, M.-N. Huang, E. Hauser, B. E. Fee, N. P. Rudemiller, J. Privratsky, J. J. Zhang, E. Reyes, D. Wang, G. A. Taylor, M. D. Gunn, D. C. Ko, D. N. Cook, , G. E. Hammer

This study identifies two novel colon-specific mononuclear phagocyte subsets that are critical for Th17 immunity in the colon.

bioRxiv · Jan 28, 2021Immunology

ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice

J. S. Bourgeois, L. Wang, M. I. Alvarez, J. Everitt, S. Awadia, E. S. Wittchen, R. Garcia-Mata, D. C. Ko

This study identifies ARHGEF26 as a host factor that enhances Salmonella invasion and inflammation through interactions with DLG1 and SCRIB, and shows its role in murine infection models.

bioRxiv · Dec 30, 2020Microbiology

Pathogen evasion of chemokine response through suppression of CXCL10

A. L. Antonia, K. D. Gibbs, E. Trahair, K. J. Pittman, B. H. Schott, J. S. Smith, S. Rajagopal, J. W. Thompson, R. L. Reinhardt, D. C. Ko

This paper identifies a mechanism by which Leishmania major evades the immune system by cleaving CXCL10, a chemokine critical for T-cell recruitment, and shows similar strategies are used by other pathogens.

bioRxiv · Apr 29, 2019Microbiology

A Real Time PCR Assay for Quantification of Parasite Burden in Murine Models of Leishmaniasis

A. L. Antonia, L. Wang, D. C. Ko

The paper develops a qPCR assay for quantifying Leishmania parasite burden in mouse models, using a conserved single-copy gene to improve accuracy over existing methods.

bioRxiv · May 2, 2018Microbiology