J. S. Smith

Phosphorylation barcodes direct biased chemokine signaling at CXCR3

The paper shows that CXCR3 chemokines use different phosphorylation barcodes to activate distinct signaling pathways, leading to varied physiological outcomes.

Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors

The paper profiles tethered agonist (TA) signaling in all 33 human aGPCRs using a platform across assays, revealing heterogeneous responses and aligning with AlphaFold2 predictions.

Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation

This study shows that isonicotinamide (INAM) extends yeast chronological lifespan by inhibiting nucleotide salvage pathways, leading to NAD+ accumulation and a hormetic stress response.

A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism

Biased agonists of the chemokine receptor CXCR3 differentially drive formation of Gαi:β-arrestin complexes

The paper shows that biased agonists of CXCR3 differentially drive the formation of Gi:β-arrestin complexes, independent of G protein signaling or β-arrestin recruitment.

Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors

The paper demonstrates that Gαi proteins can form complexes with β-arrestin, independent of their canonical G protein coupling, and these complexes can bind GPCRs and ERK.

Pathogen evasion of chemokine response through suppression of CXCL10

This paper identifies a mechanism by which Leishmania major evades the immune system by cleaving CXCL10, a chemokine critical for T-cell recruitment, and shows similar strategies are used by other pathogens.

Saccharomyces cerevisiae as a platform for assessing sphingolipid kinase inhibitors

The paper describes a high-throughput assay using Saccharomyces cerevisiae to assess sphingolipid kinase inhibitors and validates it with recombinant enzymes.