Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma
C. Su, C. L. Kent, M. Pierpoint, W. Floyd, L. Luo, N. T. Williams, Y. Ma, B. Peng, A. L. Lazarides, A. Subramanian, J. E. Himes, V. M. Perez, R. D. Hernansaiz-Ballesteros, K. E. Roche, J. L. Modliszewski, , D. G. Kirsch
This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.
bioRxiv · Jan 3, 2024 · PreprintCancer Biology