Author

D. Conole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

E. W. Tate· 3 shared A. C. Hanyaloglu· 1 shared A. H. Sims· 1 shared A. O'Mahony· 1 shared A. R. Walker· 1 shared A. Russell· 1 shared A. Santiago-Gomez· 1 shared A. Sarmiento-Castro· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

E. W. Tate

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Author profile →

3 papers

Recent·Most cited

A spatiotemporally resolved GPCR interactome reveals novel mediators of receptor agonism

M. M. Shchepinova, R. Richardson, J. W. Houghton, A. R. Walker, M. A. Safar, D. Conole, A. C. Hanyaloglu, E. W. Tate

This study uses APEX2 proteomics to map the spatiotemporal interactome of the luteinizing hormone receptor (LHR) and identifies novel interactors like RAP2B that modulate receptor signaling and trafficking.

bioRxiv · Jun 14, 2024 · PreprintBiochemistry

A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells

T. R. Jackson, A. Vuorinen, L. Josa-Cullere, K. S. Madden, D. Conole, T. J. Cogswell, I. V. L. Wilkinson, L. M. Kettyle, D. Zhang, A. O'Mahony, D. Gracias, L. McCall, R. Westwood, G. C. Terstappen, S. G. Davies, , T. Milne

The paper identifies a novel tubulin-binding molecule that induces differentiation in AML cells, reducing tumour burden and improving survival in vivo.

bioRxiv · Jun 3, 2021 · PreprintCancer Biology

Targeting STAT3 signalling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

B. M. Simoes, A. Santiago-Gomez, C. Chiodo, T. Moreira, D. Conole, S. Lovell, D. Alferez, R. Eyre, K. Spence, A. Sarmiento-Castro, B. Kohler, M. Lanzino, S. Ando, E. Marangoni, A. H. Sims, , R. B. Clarke

This study shows that SFX-01 reduces CSC activity in ER+ breast cancer by inhibiting STAT3 signaling, improving outcomes in endocrine-resistant models.

bioRxiv · Feb 3, 2020Cancer Biology