S. Lovell

Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets

The paper identifies mixed alkyl/aryl phosphonates as anti-malarial compounds that inhibit serine hydrolases with low resistance potential.

Molecular basis for the activation of the Fatty Acid Kinase complex of Staphylococcus aureus

This study investigates the structure and function of the Fatty Acid Kinase complex in Staphylococcus aureus using modeling, biochemical, and cell-based approaches, revealing key residues and interactions essential for its activity.

HSV-1 ICP0 Dimer Domain Adopts a Novel β-barrel Fold

This study determines the structure of the HSV-1 ICP0 dimer domain, revealing a novel β-barrel fold and its interactions with SUMO1.

Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole genome sequencing with histopathological features

This study integrates multi-region whole genome sequencing with histopathological data to reconstruct tumour phylogenies and identify molecular steps in prostate cancer progression and metastasis.

Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows

The paper describes a solid-phase synthesis method for creating macrocyclic peptides with fluorosulfate electrophiles, enabling chemoproteomic screening and target identification.

Structure of a dominant negative mutant reveals a stalled intermediate in anthrax protective antigen pore maturation

The paper identifies a dominant negative mutation that stalls anthrax protective antigen pore maturation at an intermediate state, revealing structural features and a regulatory mechanism for pore formation.

Potent protease inhibitors of deadly lagoviruses: rabbit hemorrhagic disease virus and European brown hare syndrome virus

The paper identifies potent protease inhibitors for RHDV1, RHDV2, and EBHSV by developing assays and analyzing structure-activity relationships.

A suite of activity-based probes to dissect the KLK activome in drug-resistant prostate cancer

The paper develops activity-based probes to analyze KLK activome dynamics in prostate cancer, revealing KLK14's role in migration and secretion into the bone microenvironment.

Post-infection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

This study shows that post-infection treatment with a deuterated protease inhibitor improves survival and reduces viral load in mice infected with SARS-CoV-2.

Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19

This study evaluates compounds targeting SARS-CoV-2 proteases Mpro and PLpro, finding limited efficacy for Mpro due to off-target inhibition of host cathepsins and no viable hits for PLpro.

The Structures of SctK and SctD from Pseudomonas aeruginosa Reveal the Interface of the Type III Secretion System Basal Body and Sorting Platform

The paper reports the structures of SctK and SctD from Pseudomonas aeruginosa, revealing their interaction interface in the T3SS and supporting a model for their functional relationship.

Targeting STAT3 signalling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

This study shows that SFX-01 reduces CSC activity in ER+ breast cancer by inhibiting STAT3 signaling, improving outcomes in endocrine-resistant models.

FDA-ARGOS: A Public Quality-Controlled Genome Database Resource for Infectious Disease Sequencing Diagnostics and Regulatory Science Research

The paper introduces FDA-ARGOS, a quality-controlled genome database for infectious disease sequencing, and demonstrates its use in diagnostics and validation.