Author

T. Milne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. Vyas· 3 shared A. Russell· 2 shared D. Zhang· 2 shared G. M. Wynne· 2 shared K. S. Madden· 2 shared S. G. Davies· 2 shared T. J. Cogswell· 2 shared T. R. Jackson· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

P. Vyas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Unique Promoter Architecture Defines Menin-KMT2A Complex Selectivity

P. R. Freire, B. Regalado, R. Takeda, E. T. Ener, G. Wan, J. A. Cutler, T. Z. Baharav, J. Brown, V. Sharlandjieva, T. Milne, R. A. Irizarry, S. A. Armstrong

The paper identifies a unique promoter architecture that defines Menin-KMT2A complex selectivity and its association with gene regulation and leukemia.

bioRxiv · Nov 2, 2026 · PreprintMolecular Biology

Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia.

D. R. Silveira, P. Chatzikyriakou, P. Casares Alaez, S. Mackie, R. Hulks, O. Yavorska, P. Siejka-Zielinska, A. Smith, M. Metzner, B. Usukhbayar, V. Penard-Lacronique, C.-X. Song, A. K. Gandhi, P. Vyas, T. Milne, , L. Quek

This study shows that IDH2 mutations in AML block differentiation by altering H3K27 methylation, and that Enasidenib can reverse this block by modulating chromatin states.

bioRxiv · Aug 24, 2023 · PreprintCancer Biology

Pharmacologic Inhibition of DYRK1A Results in MYC Hyperactivation and ERK Hyperphosphorylation rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

C. Hurtz, V. S. S. A. Ayyadevara, G. Wertheim, J. Chukinas, J. P. Loftus, S. J. Lee, A. Kumar, R. S. Bhansali, S. Swaminathan, H. Geng, T. Milne, X. Hua, K. M. Bernt, T. Besson, J. Shi, , S. K. Tasian

This study shows that inhibiting DYRK1A in KMT2A-R ALL cells leads to MYC upregulation and ERK hyperphosphorylation, making them sensitive to BCL2 inhibition.

bioRxiv · Oct 2, 2022 · PreprintCancer Biology

A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells

T. R. Jackson, A. Vuorinen, L. Josa-Cullere, K. S. Madden, D. Conole, T. J. Cogswell, I. V. L. Wilkinson, L. M. Kettyle, D. Zhang, A. O'Mahony, D. Gracias, L. McCall, R. Westwood, G. C. Terstappen, S. G. Davies, , T. Milne

The paper identifies a novel tubulin-binding molecule that induces differentiation in AML cells, reducing tumour burden and improving survival in vivo.

bioRxiv · Jun 3, 2021 · PreprintCancer Biology

A phenotypic screen identifies a compound series that induces differentiation of acute myeloid leukemia cells in vitro and shows anti-tumour effects in vivo

L. Jose-Cullere, K. S. Madden, T. J. Cogswell, T. R. Jackson, T. S. Carter, D. Zhang, G. Trevitt, S. G. Davies, P. Vyas, G. M. Wynne, T. Milne, A. Russell

bioRxiv · Dec 18, 2020 · PreprintCancer Biology