Author

K. Spence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. H. Sims· 1 shared A. R. Mohammed· 1 shared A. Santiago-Gomez· 1 shared A. Sarmiento-Castro· 1 shared B. Gyorffy· 1 shared B. Kohler· 1 shared B. M. Simoes· 1 shared C. Behan· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. H. Sims

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation

S. Cabral, J. Parsons, H. Harrison, T. Kedward, P. Fullwood, K. Spence, D. Lefley, D. Barden, J. Haworth, J. Watson, K. Tsafou, C. Behan, M. J. Dunning, N. Ali, B. Gyorffy, , R. Clarke

The paper identifies osteomodulin as a promoter of breast cancer bone metastasis through CDK1 activation using proteomics and phosphoproteomics analysis of patient-derived tumors.

bioRxiv · Nov 3, 2023 · PreprintCancer Biology

High speed, three-dimensional imaging reveals chemotactic behavior specific to human-infective Leishmania parasites

R. C. Findlay, M. Osman, K. Spence, P. M. Kaye, P. B. Walrad, L. G. Wilson

This study uses high-speed 3D imaging to show that Leishmania parasites change their swimming behavior during their lifecycle, with specific adaptations for infecting humans.

bioRxiv · Jul 30, 2020Biophysics

Targeting STAT3 signalling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

B. M. Simoes, A. Santiago-Gomez, C. Chiodo, T. Moreira, D. Conole, S. Lovell, D. Alferez, R. Eyre, K. Spence, A. Sarmiento-Castro, B. Kohler, M. Lanzino, S. Ando, E. Marangoni, A. H. Sims, , R. B. Clarke

This study shows that SFX-01 reduces CSC activity in ER+ breast cancer by inhibiting STAT3 signaling, improving outcomes in endocrine-resistant models.

bioRxiv · Feb 3, 2020Cancer Biology

Novel Wolbachia strains in Anopheles malaria vectors from Sub-Saharan Africa

C. L. Jeffries, G. G. Lawrence, G. Golovko, M. Kristan, J. Orsborne, K. Spence, E. Hurn, J. Bandibabone, L. M. Tantely, F. N. Raharimalala, K. Keita, D. Camara, Y. Barry, F. Watsenga, E. Z. Manzambi, , T. Walker

The paper identifies novel Wolbachia strains in multiple Anopheles species from Sub-Saharan Africa and assesses their association with Plasmodium infection.

bioRxiv · Jul 17, 2018Microbiology