Author

D. F. Mega

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3

Frequent Co-Authors

A. Kipar· 3 shared A. Kirby· 3 shared E. G. Bentley· 3 shared J. A. Hiscox· 3 shared J. P. Stewart· 3 shared P. Sharma· 3 shared A. Owen· 2 shared C. Bramwell· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

A. Kipar

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3 papers

Recent·Most cited

The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19.

R. Penrice-Randal, E. G. Bentley, P. Sharma, A. Kirby, I. Donovan-Banfield, A. Kipar, D. F. Mega, C. Bramwell, J. Sharp, A. Owen, J. A. Hiscox, J. P. Stewart

This study examines how molnupiravir and nirmatrelvir affect SARS-CoV-2 genome diversity in immunocompromised mice, finding reduced viral load and specific mutations but no major consensus sequence changes.

bioRxiv · Feb 27, 2024Pharmacology & Toxicology

Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated in vivo

S. Gu, E. G. Bentley, R. I. Milligan, A. M. Almuqrin, P. Sharma, A. Kirby, D. F. Mega, A. Kipar, M. Erdmann, J. Bazire, K. J. Heesom, P. A. Lewis, I. Donovan-Banfield, C. Reston, I. Webb, , D. A. Matthews

This study shows that a recombinant SARS-CoV-2 virus lacking ORF10 start and internal methionine codons is attenuated in hamsters, with reduced lower respiratory tract viral titre and increased reversion to wild-type.

bioRxiv · Aug 4, 2023 · PreprintMicrobiology

SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19

E. G. Bentley, A. Kirby, P. Sharma, A. Kipar, D. F. Mega, C. Bramwell, R. Penrice-Randal, T. Prince, J. C. Brown, J. Zhou, G. R. Screaton, W. S. Barclay, A. Owen, J. A. Hiscox, J. P. Stewart

This study compares the severity of SARS-CoV-2 Omicron-B.1.1.529, Pango B, and Delta variants in a mouse model, finding Omicron causes less severe disease with lower viral load and inflammation.

bioRxiv · Dec 26, 2021 · PreprintMicrobiology