M. Erdmann

The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses

This study shows that the N-terminal fragment of α-dystroglycan blocks SARS-CoV-2 and other enveloped viruses in cell culture and animal models.

Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated in vivo

This study shows that a recombinant SARS-CoV-2 virus lacking ORF10 start and internal methionine codons is attenuated in hamsters, with reduced lower respiratory tract viral titre and increased reversion to wild-type.

SARS-CoV-2 NSP12 associates with the TRiC complex and the P323L substitution is a host adaption.

The paper identifies NSP12's interaction with the TRiC complex and shows the P323L substitution enhances viral adaptation by reducing sensitivity to PP2A perturbations.

Development of SARS-CoV-2 replicons for the ancestral virus and variant of concern Delta for antiviral screening.

The paper develops SARS-CoV-2 replicons for the ancestral virus and Delta variant to screen antiviral compounds, showing sensitivity to remdesivir.

Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.