Author

J. Bazire

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 1 Organism:non-human primate· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. D. Davidson· 4 shared D. A. Matthews· 3 shared M. Erdmann· 3 shared J. A. Hiscox· 2 shared T. Jearanaiwitayakul· 2 shared X. Dong· 2 shared A. Darby· 1 shared A. Kipar· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersMicrobiology

A. D. Davidson

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Author profile →

4 papers

Recent·Most cited

Broad-spectrum antiviral activity of clinically approved CYP3A inhibitors against pathogenic human coronaviruses in vitro

L. Gallucci, J. Bazire, A. D. Davidson, I. L. Shytaj

This study shows that cobicistat and ritonavir have antiviral activity against multiple SARS-CoV-2 variants and other human coronaviruses, with cobicistat being more potent.

bioRxiv · Aug 23, 2023 · PreprintMicrobiology

Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated in vivo

S. Gu, E. G. Bentley, R. I. Milligan, A. M. Almuqrin, P. Sharma, A. Kirby, D. F. Mega, A. Kipar, M. Erdmann, J. Bazire, K. J. Heesom, P. A. Lewis, I. Donovan-Banfield, C. Reston, I. Webb, , D. A. Matthews

This study shows that a recombinant SARS-CoV-2 virus lacking ORF10 start and internal methionine codons is attenuated in hamsters, with reduced lower respiratory tract viral titre and increased reversion to wild-type.

bioRxiv · Aug 4, 2023 · PreprintMicrobiology

Development of SARS-CoV-2 replicons for the ancestral virus and variant of concern Delta for antiviral screening.

M. Erdmann, M. Kavanagh Williamson, T. Jearanaiwitayakul, J. Bazire, D. A. Matthews, A. D. Davidson

The paper develops SARS-CoV-2 replicons for the ancestral virus and Delta variant to screen antiviral compounds, showing sensitivity to remdesivir.

bioRxiv · Oct 11, 2022Microbiology

Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

X. Dong, H. Goldswain, R. Penrice-Randal, G. Shawli, T. Prince, M. K. Williamson, N. Randle, B. Jones, F. J. Salguero, J. Tree, Y. Hall, C. Hartley, M. Erdmann, J. Bazire, T. Jearanaiwitayakul, , J. A. Hiscox

The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.

bioRxiv · Dec 23, 2021 · PreprintMicrobiology