Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex
D. Gauto, L. Estrozi, C. Schwieters, G. Effantin, P. Macek, r. sounier, A. C. Sivertsen, E. Schmidt, R. Kerfah, G. Mas, J.-P. Colletier, P. Guntert, A. Favier, G. Schoehn, J. Boisbouvier, P. Schanda
The paper integrates NMR and cryo-EM to determine the atomic structure of a large enzyme complex, achieving high precision and accuracy beyond the limitations of each method individually.
bioRxiv · Dec 16, 2018Biophysics