RNA binding kinase UHMK1 regulates therapy induced metabolic adaptation in BRAFV600 melanoma
L. K. Smith, T. Parmenter, M. Kleinschmidt, E. P. Kusnadi, J. Kang, C. A. Martin, P. Lau, J. Lorent, A. S. Trigos, T. Ward, A. D. Rao, E. J. Lelliott, K. E. Sheppard, D. Goode, R. J. Hicks, , G. A. McArthur
The paper identifies UHMK1 as a regulator of metabolic adaptation in BRAFV600 melanoma under targeted therapy, showing its role in mRNA transport and translation and its impact on therapy resistance.
bioRxiv · Sep 21, 2019Cancer Biology