Cancer BiologybioRxiv
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis
E. P. Kusnadi, A. S. Trigos, C. Cullinane…·R. B. Pearson
The paper shows that combining CX-5461 with pathway inhibitors improves efficacy by suppressing metabolic regulators, but resistance arises through translational re-wiring and cAMP pathway activation in blood cancers.
DOI 10.15252/embj.2020105111