Author

L. K. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. C. Lewis· 1 shared A. D. Rao· 1 shared A. S. Trigos· 1 shared B. Treanor· 1 shared C. A. Martin· 1 shared C. Cullinane· 1 shared D. B. Ulanet· 1 shared D. Goode· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. C. Lewis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inhibition of pyrimidine biosynthesis targets protein translation in AML.

L. M. Kats, J. So, A. C. Lewis, L. K. Smith, K. Stanley, L. Pijpers, P. Dominguez, S. J. Hogg, S. Vervoort, R. W. Johnstone, G. McDonald, D. B. Ulanet, J. Murtie, E. Gruber

This study shows that DHODH inhibitors block protein translation in AML by reducing YY1 and enhance AML treatment while sparing normal blood cells.

bioRxiv · Sep 24, 2021 · PreprintCancer Biology

Galectin-9 regulates the threshold of B cell activation and autoimmunity

L. K. Smith, K. Fawaz, B. Treanor

This study shows that galectin-9 regulates B cell activation thresholds and prevents autoimmunity by modulating BCR and TLR interactions in B-1a cells.

bioRxiv · Nov 3, 2020Immunology

RNA binding kinase UHMK1 regulates therapy induced metabolic adaptation in BRAFV600 melanoma

L. K. Smith, T. Parmenter, M. Kleinschmidt, E. P. Kusnadi, J. Kang, C. A. Martin, P. Lau, J. Lorent, A. S. Trigos, T. Ward, A. D. Rao, E. J. Lelliott, K. E. Sheppard, D. Goode, R. J. Hicks, , G. A. McArthur

The paper identifies UHMK1 as a regulator of metabolic adaptation in BRAFV600 melanoma under targeted therapy, showing its role in mRNA transport and translation and its impact on therapy resistance.

bioRxiv · Sep 21, 2019Cancer Biology