BioengineeringbioRxiv
FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells
I. T. Warren, D. Guiggey, A. Chiang…·N. Parashurama
This study shows that depletion of FOXA1/2 in human liver cells reprograms differentiation state and metabolism, promoting de-differentiation and pluripotency.
DOI 10.1096/fj.202101506rrr