Author

D. H. Spencer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Miller· 2 shared D. C. Link· 2 shared F. Ferraro· 2 shared J. E. Payton· 2 shared J. F. DiPersio· 2 shared J. S. Welch· 2 shared R. B. Day· 2 shared R. S. Fulton· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

C. Miller

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Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 22, 2023

Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis

N. Arthur, K. A. Christensen, K. Mannino…·F. Ferraro

This study shows that MBI MYC mutations alter MYC localization and disrupt mRNA subcellular distribution and turnover, promoting leukemogenesis.

DOI 10.1101/2023.10.22.563493

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintSep 3, 2021

Immunosuppression and Outcomes in Acute Myeloid Leukemia

F. Ferraro, C. Miller, K. Christensen…·T. J. Ley

This study identifies immunosuppressive features in AML cells associated with poor outcomes in patients treated with standard chemotherapy.

DOI 10.1101/2021.09.03.458879

humanwhole-exome sequencing

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMar 3, 2021

Genome-wide analysis of focal DNA hypermethylation in IDH-mutant AML samples

E. R. Wilson, N. Helton, S. E. Heath…·D. H. Spencer

This study identifies focal DNA hypermethylation in IDH-mutant AML samples and links it to TET2 and DNMT3A activity, with implications for AML pathogenesis.

DOI 10.1101/2021.03.03.433799

humanDNA methylation

𝕏 PostBluesky