Immunosuppression and Outcomes in Acute Myeloid Leukemia
F. Ferraro, C. Miller, K. Christensen…·T. J. Ley
This study identifies immunosuppressive features in AML cells associated with poor outcomes in patients treated with standard chemotherapy.
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3 papers
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F. Ferraro, C. Miller, K. Christensen…·T. J. Ley
This study identifies immunosuppressive features in AML cells associated with poor outcomes in patients treated with standard chemotherapy.
G. Hadwiger, O. di Martino, M. A. Ferris…·J. S. Welch
This study screens bexarotene derivatives to identify compounds with enhanced anti-leukemic activity in AML, finding that dual RARA/RXRA activity and structural modifications affect potency and metabolic stability.
E. R. Wilson, N. Helton, S. E. Heath…·D. H. Spencer
This study identifies focal DNA hypermethylation in IDH-mutant AML samples and links it to TET2 and DNMT3A activity, with implications for AML pathogenesis.