Author

D. Hendriks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

H. Clevers· 2 shared A. gutierrez-Guerrero· 1 shared A. Krug· 1 shared B. Artegiani· 1 shared E. Bokobza· 1 shared E. Verhoeyen· 1 shared F. Bost· 1 shared F. Larbret· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

H. Clevers

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Author profile →

2 papers

Recent·Most cited

Nanoblades allow high-level genome editing in organoids

V. Tiroille, A. Krug, E. Bokobza, M. Bulcaen, M. Ensinck, M. Geurts, D. Hendriks, F. Vermeulen, F. Larbret, A. gutierrez-Guerrero, M. Louise, R. Gijsbers, P. E. Mangeot, H. Clevers, M. Carlon, , E. Verhoeyen

This paper introduces nanoblade technology for efficient, low-toxicity genome editing in organoids, achieving up to 80% gene knockout in murine and human organoids.

bioRxiv · Aug 4, 2022 · PreprintBioengineering

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR/Cas9 precision genome editing

B. Artegiani, D. Hendriks, J. Beumer, R. Kok, X. Zheng, I. Joore, S. Chuva de Sousa Lopes, J. van Zon, S. Tans, H. Clevers

This paper introduces CRISPR-HOT, a method for efficient knock-in of exogenous DNA in human organoids without requiring homology templates or TP53 inactivation, and demonstrates its application in studying hepatocyte division and ploidy.

bioRxiv · Jan 15, 2020Cell Biology