Author

S. Tans

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:organoid / primary culture· 2 Organism:bacteria (other)· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

H. Clevers· 2 shared J. van Zon· 2 shared X. Zheng· 2 shared B. Artegiani· 1 shared D. Hendriks· 1 shared F. Buke· 1 shared G. Bokinsky· 1 shared G. Huelsz-Prince· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiophysics

H. Clevers

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Following cell type transitions in space and time by combining live-cell tracking and endpoint cell identity in intestinal organoids

X. Zheng, M. Betjes, Y. Goos, G. Huelsz-Prince, H. Clevers, J. van Zon, S. Tans

The paper introduces TypeTracker, a method combining live-cell tracking and endpoint cell identity to study differentiation trajectories in intestinal organoids, revealing new insights into cell type transitions and spatial organization.

bioRxiv · Jun 27, 2022 · PreprintBiophysics

ppGpp is a bacterial cell size regulator

F. Buke, J. Grilli, M. Cosentino Lagomarsino, G. Bokinsky, S. Tans

This study shows ppGpp regulates bacterial cell size by controlling growth rate and division, leading to size homeostasis.

bioRxiv · Jun 16, 2020Microbiology

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR/Cas9 precision genome editing

B. Artegiani, D. Hendriks, J. Beumer, R. Kok, X. Zheng, I. Joore, S. Chuva de Sousa Lopes, J. van Zon, S. Tans, H. Clevers

This paper introduces CRISPR-HOT, a method for efficient knock-in of exogenous DNA in human organoids without requiring homology templates or TP53 inactivation, and demonstrates its application in studying hepatocyte division and ploidy.

bioRxiv · Jan 15, 2020Cell Biology