GLP-1R is downregulated in beta cells of NOD mice and T1D patients
A. Recino, K. Barkan, A. Schmidt-Christensen, J. Nilsson, N. Holmes, D. Howie, D. Holmberg, P. Larsson, M. Flodstrom-Tullberg, L. Laraia, D. R. Spring, J. Hecksher-Sorensen, A. Cooke, G. Ladds, M. Wallberg
This study shows that GLP-1R is downregulated in beta cells of NOD mice and T1D patients, likely due to accelerated degradation, and suggests a role in autoimmune inflammation.
bioRxiv · Nov 17, 2019 · PreprintPhysiology