Author

K. Barkan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Physiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

G. Ladds· 6 shared C. A. Reynolds· 3 shared G. Deganutti· 3 shared B. Frenguelli· 2 shared B. Preti· 2 shared D. Safitri· 2 shared M. Leuenberger· 2 shared M. Lochner· 2 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersPharmacology & Toxicology

G. Ladds

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6 papers

Recent·Most cited

Cancer-Associated Mutations Enhance The Sensitivity Of The Trupath GαQ/11 System

D. Safitri, M. Harris, A. Pearce, X. Huang, M. Rosa, K. Barkan, E. Wills, M. Marti-Solano, M. Falk, G. Ladds

The paper modifies Gq and G11 biosensors to enhance sensitivity for detecting Gq/11 activation in GPCRs, including those with cancer-associated mutations.

bioRxiv · Sep 1, 2022 · PreprintPharmacology & Toxicology

Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

G. Deganutti, K. Barkan, B. Preti, M. Leuenberger, M. Wall, B. Frenguelli, M. Lochner, G. Ladds, C. A. Reynolds

The paper uses molecular dynamics simulations and mutagenesis to study agonist binding to the A1 receptor, identifying new residues and binding modes of CPA-related ligands.

bioRxiv · Oct 22, 2020Pharmacology & Toxicology

A Multisite Model of Allosterism for the Adenosine A1 Receptor

G. Deganutti, K. Barkan, G. Ladds, C. A. Reynolds

The paper models allosteric behavior of the adenosine A1 receptor using simulations of PAMs and agonists to explain their functional selectivity and binding properties.

bioRxiv · Oct 14, 2020Biophysics

Pharmacological Characterisation of Novel Adenosine Receptor A3R Antagonists

K. Barkan, P. Lagarias, M. Stampelou, D. Stamatis, S. Hoare, K.-N. Klotz, E. Vrontaki, A. Kolocouris, G. Ladds

This study characterizes a selective A3R antagonist, K18, and identifies its binding mode through molecular dynamics simulations and mutagenesis.

bioRxiv · Apr 28, 2020Pharmacology & Toxicology

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

M. Wall, E. Hill, R. Huckstepp, K. Barkan, G. Deganutti, M. Leuenberger, B. Preti, I. Winfield, S. Carvalho, A. Suchankova, H. Wei, D. Safitri, X. Huang, W. Imlach, C. La Mache, , B. Frenguelli

The paper identifies BnOCPA as an A1R agonist that selectively activates Gαob, providing analgesia without cardiorespiratory depression.

bioRxiv · Apr 4, 2020Physiology

GLP-1R is downregulated in beta cells of NOD mice and T1D patients

A. Recino, K. Barkan, A. Schmidt-Christensen, J. Nilsson, N. Holmes, D. Howie, D. Holmberg, P. Larsson, M. Flodstrom-Tullberg, L. Laraia, D. R. Spring, J. Hecksher-Sorensen, A. Cooke, G. Ladds, M. Wallberg

This study shows that GLP-1R is downregulated in beta cells of NOD mice and T1D patients, likely due to accelerated degradation, and suggests a role in autoimmune inflammation.

bioRxiv · Nov 17, 2019 · PreprintPhysiology