Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice
L. Muniappan, M. Okuyama, A. Javidan, D. Thiagarajan, W. Jiang, J. J. Moorleghen, L. Yang, A. Balakrishnan, D. Howatt, H. A. Uchida, T. C. Saido, V. Subramanian
This study shows that calpain-2 depletion reduces abdominal aortic aneurysm (AAA) progression and rupture in mice by preserving cytoskeletal proteins and ECM integrity.
bioRxiv · Apr 15, 2020Pathology