A. Balakrishnan

A CRISPR homing screen finds a chloroquine resistance transporter-like protein of the Plasmodium oocyst essential for mosquito transmission of malaria

This study uses a CRISPR homing screen to identify essential genes for malaria transmission in mosquito stages, finding a chloroquine resistance transporter-like protein critical for oocyst development.

Self-quenched fluorophore-DNA labels for super-resolution fluorescence microscopy

The paper introduces self-quenched fluorophore-DNA labels to reduce background signal in super-resolution microscopy, improving imaging performance in STED and SMLM.

The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways

This study identifies CK2-dependent phosphorylation and ubiquitination as essential for FAM134B and FAM134C-driven ER-phagy activation during mTOR inhibition.

Synergizing exchangeable fluorophore labels for multi-target STED microscopy

This paper demonstrates 6-target STED microscopy using exchangeable labels, improving multiplexing capabilities and reducing photobleaching in live-cell imaging.

SMPD3 suppresses IDH mutant tumor growth via dual autocrine-paracrine roles

This study shows SMPD3 suppresses IDH mutant glioma growth through autocrine and paracrine mechanisms, with higher SMPD3 linked to longer survival in patients.

Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice

This study shows that calpain-2 depletion reduces abdominal aortic aneurysm (AAA) progression and rupture in mice by preserving cytoskeletal proteins and ECM integrity.

Galectin-1 promotes the invasion of bladder cancer urothelia through their matrix milieu

This study identifies Galectin-1 as a driver of bladder cancer invasion through matrix interactions, showing its role in promoting adhesion, proliferation, and mesenchymal-like phenotypes.