Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α
S. Mann, N. Hadad, M. Nelson, A. Rothman, R. Sathiaseelan, S. Ali-Mondal, M.-P. Agbaga, A. Unnikrishnan, S. Malayannan, J. Hawse, D. Huffmam, W. M. Freeman, M. B. Stout
This study shows 17α-estradiol improves metabolic parameters and slows aging in male mice and rats through estrogen receptor α, primarily acting in the liver and hypothalamus.
bioRxiv · Jun 2, 2020Physiology