PhysiologybioRxiv
Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α
S. Mann, N. Hadad, M. Nelson…·M. B. Stout
This study shows 17α-estradiol improves metabolic parameters and slows aging in male mice and rats through estrogen receptor α, primarily acting in the liver and hypothalamus.