Author

S. Mann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

R. Sathiaseelan· 3 shared M. Kamal· 2 shared M. Stout· 2 shared S. Ali Mondal· 2 shared W. M. Freeman· 2 shared A. Ashworth· 1 shared A. Rothman· 1 shared A. Unnikrishnan· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersPhysiology

R. Sathiaseelan

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Author profile →

5 papers

Recent·Most cited

De novo design of drug-binding proteins with predictable binding energy and specificity

L. Lu, X. Gou, S. Tan, S. Mann, H. Yang, X. Zhong, D. Gazgalis, J. Valdiviezo, H. Jo, Y. Wu, M. Diolaiti, A. Ashworth, N. Polizzi, W. DeGrado

This paper designs drug-binding proteins with low nanomolar affinity and predictable specificity using computational methods, validated by experimental measurements and structural analysis.

bioRxiv · Dec 23, 2023 · PreprintBiophysics

Metabolic benefits of 17α-estradiol in liver are partially mediated by ERβ in male mice

S. Ali Mondal, S. Mann, C. van der Linden, R. Sathiaseelan, M. Kamal, S. Das, M. Bubak, S. Logan, B. F. Miller, M. Stout

This study shows that 17α-estradiol's metabolic benefits in male mice are partially mediated by ERβ in liver, specifically affecting SCD1 and TGF-β1 production.

bioRxiv · Mar 25, 2023 · PreprintPhysiology

17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice

S. Ali Mondal, R. Sathiaseelan, S. Mann, M. Kamal, W. Luo, T. Saccon, J. Isola, R. Peeler, T. Li, W. M. Freeman, B. Miller, M. Stout

This study shows that 17-E2 reduces liver fibrosis in male mice by decreasing collagen synthesis and increasing collagen degradation.

bioRxiv · Jun 16, 2022Physiology

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

S. Mann, N. Hadad, M. Nelson, A. Rothman, R. Sathiaseelan, S. Ali-Mondal, M.-P. Agbaga, A. Unnikrishnan, S. Malayannan, J. Hawse, D. Huffmam, W. M. Freeman, M. B. Stout

This study shows 17α-estradiol improves metabolic parameters and slows aging in male mice and rats through estrogen receptor α, primarily acting in the liver and hypothalamus.

bioRxiv · Jun 2, 2020Physiology

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

J. Koszela, N. Pham, D. Evans, S. Mann, I. Perez-Pi, S. Shave, D. Ceccarelli, F. Sicheri, M. Tyers, M. Auer

This paper introduces a fluorescent confocal on-bead assay to real-time track ubiquitination cascades and identifies new inhibitor activities against Ube1.

bioRxiv · Feb 21, 2018Biochemistry