Pharmacology & ToxicologybioRxivPreprint
Drug targeting to sites of oxidative stress using the Baeyer-Villiger reaction
T. D. Avery, J. Li, D. J. L. Turner…·A. D. Abell
The paper develops a 1,2-dicarbonyl compound that selectively activates Nrf2 at sites of oxidative stress, reversing pain in mice and offering a targeted approach for treating oxidative stress-related disorders.
DOI 10.1101/2021.09.03.458872