Author

D. J. Slade

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:human· 8 Assay:proteomics· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:genome assembly· 3 Organism:bacteria (other)· 2 Approach:biophysical modeling· 2 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

A. Umana· 7 shared B. E. Sanders· 5 shared C. C. Yoo· 4 shared M. A. Casasanta· 4 shared S. S. Verbridge· 4 shared B. Udayasuryan· 3 shared T. T. D. Nguyen· 3 shared A. J. Duncan· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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7 shared papersMicrobiology

A. Umana

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Type 4 pili mediated natural competence in Fusobacterium nucleatum

B. E. Sanders, A. Umana, T. T. D. Nguyen, K. J. Williams, C. C. Yoo, M. A. Casasanta, B. Wozniak, D. J. Slade

This study characterizes Type 4 pili-mediated natural competence in Fusobacterium nucleatum, showing DNA uptake and chromosomal integration require specific pilus components and DNA methylation.

bioRxiv · Jun 9, 2023 · PreprintMicrobiology

DNA methyltransferase enhanced Fusobacterium nucleatum genetics

A. Umana, T. T. D. Nguyen, B. E. Sanders, K. Williams, B. Wozniak, D. J. Slade

This paper demonstrates using DNA methyltransferases from Fusobacterium nucleatum to bypass restriction-modification systems, enabling efficient genetic modification of previously recalcitrant strains.

bioRxiv · Jul 20, 2022 · PreprintMicrobiology

Mucosal microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients

H. N. H. Tran, T. Nguyen Hoang Thu, P. H. Nguyen, C. N. Vo, K. V. Doan, C. Nguyen Ngoc Minh, N. T. Nguyen, V. N. D. Ta, K. A. Vu, T. D. Hua, T. N. T. Nguyen, T. Pham Duc, T. Trinh Van, B. L. Duong, P. M. Nguyen, , H. Chung The

This study examines the mucosal microbiome and Fusobacterium genomics in Vietnamese colorectal cancer patients, finding increased abundance of oral bacteria in tumors and genomic diversity within Fusobacterium species.

bioRxiv · Feb 25, 2022 · PreprintMicrobiology

CRISPR-Cas systems in Fusobacterium: An untapped genetic frontier

A. Umana, D. J. Slade

This paper identifies and characterizes CRISPR-Cas systems in Fusobacterium, providing a roadmap for developing genetic tools to study its role in cancer.

bioRxiv · Jan 21, 2022 · PreprintMicrobiology

Fusobacterium nucleatum induces pancreatic cancer cell proliferation and migration by regulating host autocrine and paracrine signaling

B. Udayasuryan, T. T. D. Nguyen, A. Umana, R. A. Ahmad, L. M. Roberts, P. Sobol, S. D. Jones, J. M. Munson, D. J. Slade, S. S. Verbridge

This study shows that Fusobacterium nucleatum in pancreatic cancer promotes cell proliferation and migration through autocrine and paracrine cytokine signaling.

bioRxiv · Nov 19, 2021 · PreprintCancer Biology

The Shigella type III effector protein OspB is a cysteine protease

T. E. Wood, K. A. Westervelt, J. M. Yoon, H. D. Eshleman, H. Burnes, R. Levy, D. J. Slade, C. F. Lesser, M. B. Goldberg

This paper identifies OspB as a cysteine protease in Shigella spp. and shows it interacts with the TORC1 pathway in yeast through proteolytic cleavage of Tco89p.

bioRxiv · Sep 1, 2021 · PreprintMicrobiology

Fusobacterium nucleatum host cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration

M. A. Casasanta, C. C. Yoo, B. Udayasuryan, B. E. Sanders, A. Umana, Y. Zhang, H. Peng, A. J. Duncan, Y. Wang, L. Li, S. S. Verbridge, D. J. Slade

This study shows that Fusobacterium nucleatum binding and invasion of colorectal cancer cells induces IL-8 and CXCL1 secretion, promoting cancer cell migration and immune signaling.

bioRxiv · Jan 15, 2020Cancer Biology

Reevaluating the Fusobacterium Virulence Factor Landscape

A. Umana, B. E. Sanders, C. C. Yoo, M. A. Casasanta, B. Udayasuryan, S. S. Verbridge, D. J. Slade

The paper redefines the virulence factor landscape of Fusobacterium using complete genomes and experimental validation, showing previously misclassified strains can invade human cells.

bioRxiv · Jan 29, 2019 · PreprintMicrobiology

FusoPortal: An interactive repository of hybrid MinION sequenced Fusobacterium genomes improves gene identification and characterization

B. E. Sanders, A. Umana, J. A. Lemkul, D. J. Slade

FusoPortal provides a repository of hybrid MinION sequenced Fusobacterium genomes, improving gene identification and characterization by correcting misannotations and offering downloadable genomic data.

bioRxiv · Apr 22, 2018Microbiology

Fusobacterium genomics using MinION and Illumina sequencing enables genome completion and correction

S. M. Todd, R. E. Settlage, K. K. Lahmers, D. J. Slade

This paper completes and corrects Fusobacterium genomes using MinION and Illumina sequencing, revealing a genomic inversion in a reference strain and providing a genomic resource.

bioRxiv · Apr 20, 2018Microbiology

N-(3-Oxododecanoyl)-L-Homoserine Lactone Interactions In The Breast Tumor Microenvironment: Implications For Breast Cancer Viability And Proliferation In Vitro

B. N. Balhouse, L. Patterson, E. M. Schmelz, D. J. Slade, S. S. Verbridge

This study investigates how the bacterial quorum-sensing molecule OdDHL affects breast cancer cell viability and proliferation under different microenvironmental conditions.

bioRxiv · Jun 13, 2017Cancer Biology

FplA From Fusobacterium nucleatum Is A Type Vd Autotransporter Phospholipase With A Proposed Role In Altered Host Signaling And Evasion Of Autophagy

M. A. Casasanta, C. C. Yoo, H. B. Smith, A. J. Duncan, K. Cochrane, A. C. Varano, E. Allen-Vercoe, D. J. Slade

This paper characterizes FplA, a Type Vd autotransporter phospholipase from F. nucleatum, showing its potential role in modulating host signaling and evading autophagy.

bioRxiv · May 10, 2017Microbiology