Structural Elucidation of a Protective B cell Epitope on Outer Surface Protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi
M. J. Rudolph, S. Davis, H. M. E. Haque, D. D. Weis, D. J. Vance, C. L. Piazza, M. Ejemel, L. A. Cavacini, Y. Wang, L. Mbow, R. D. Gilmore, N. J. Mantis
This paper determines the crystal structure of a protective B cell epitope on OspC, revealing its quaternary nature and informing vaccine design for Lyme disease.
bioRxiv · Nov 28, 2022 · PreprintImmunology