N. J. Mantis

Quantitating SARS-CoV-2 Neutralizing Antibodies from Human Dried Blood Spots

This study evaluates the use of dried blood spots (DBS) to quantify SARS-CoV-2 neutralizing antibodies using multiple assays, finding that DBS eluates can reliably measure neutralizing titers.

Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)

The paper identifies unique borreliacidal epitopes on OspA using VHHs and evaluates their reactivity across OspA serotypes.

Inflammatory Profiles Induced following Intranasal Vaccination with Ricin Toxin-Immune Complexes

This study investigates the inflammatory response and antibody induction following intranasal vaccination with ricin toxin-immune complexes (RICs) in mice, finding that while RICs elicit a reduced inflammatory profile compared to ricin toxin, IL-6 neutralization does not affect antibody response kinetics or magnitude.

Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor binding domain (RBD)

This paper evaluates the stability and immunogenicity of a SARS-CoV-2 RBD VLP vaccine candidate formulated with different adjuvants and finds that AP and AH adjuvants provide comparable immunogenicity to AV, with AP showing higher neutralizing titers.

mRNA delivery of dimeric human IgA protects mucosal tissues from bacterial infection

The paper demonstrates that mRNA-delivered human IgA can protect mucosal tissues from bacterial infection by trafficking to mucosal sites and limiting bacterial invasion.

Structural Elucidation of a Protective B cell Epitope on Outer Surface Protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

This paper determines the crystal structure of a protective B cell epitope on OspC, revealing its quaternary nature and informing vaccine design for Lyme disease.

The Flexible Linker of Decorin Binding Protein A from Borrelia burgdorferi is a Target of Antibodies in Lyme disease

The paper identifies a specific DbpA epitope targeted by antibodies in Lyme disease patients, suggesting it may block B. burgdorferi colonization.

Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine

This paper demonstrates that a two-dose regimen of RiVax provides durable protection against ricin toxin challenge in mice for up to one year.

Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis

This paper identifies mucoricin, a ricin-like toxin produced by Mucorales fungi, critical for mucormycosis pathogenesis and a potential therapeutic target.

Sites of Vulnerability on Ricin B Chain Revealed through Epitope Mapping of Toxin-Neutralizing Monoclonal Antibodies

This study identifies the epitopes of two classes of ricin toxin-neutralizing monoclonal antibodies by mapping their binding to specific domains of the RTB subunit.

Endpoint and Epitope-specific Antibody Responses as Correlates of Vaccine-mediated Protection of Mice against Ricin Toxin

This paper develops a multivariate model using antibody endpoint titers and epitope-specific inhibition values to predict vaccine-mediated protection against ricin toxin in mice.

Intracellular Neutralization of Ricin Toxin by Single Domain Antibodies Targeting the Active Site Pocket

The paper identifies three potent single-domain antibodies that neutralize ricin toxin by targeting its active site, with structural insights into their mechanism of action.

Inhibition of Invasive Salmonella by Orally Administered IgA and IgG Monoclonal Antibodies

This study shows orally administered IgA and SIgA monoclonal antibodies can reduce Salmonella Typhimurium uptake in Peyers patches, while IgG is less effective, highlighting the need for improved formulations to sustain mAb activity in the gut.