Structural basis for CCR6 modulation by allosteric antagonists
D. J. Wasilko, B. S. Gerstenberger, K. A. Farley, W. Li, J. Alley, M. E. Schnute, R. J. Unwalla, J. Victorino, K. K. Crouse, R. Ding, P. V. Sahasrabudhe, F. Vincent, R. K. Frisbie, A. Dermenci, A. Flick, , H. Wu
This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.
bioRxiv · Apr 5, 2024Biochemistry