A. Barth

DNA supercoiling enhances DNA condensation by ParB proteins

This study shows DNA supercoiling enhances ParB-DNA condensation, forming partition complexes at lower ParB concentrations than on relaxed DNA.

Rhizaria in the oligotrophic ocean exhibit clear temporal and vertical variability

This study quantifies Rhizaria abundance and vertical distribution over a year in the Sargasso Sea, showing taxonomic partitioning and environmental influences.

Microeukaryote metabolism across the western North Atlantic Ocean revealed through autonomous underwater profiling

The paper uses metatranscriptomic and metaproteomic analysis of plankton biomass collected across a 1,050 km transect in the western North Atlantic Ocean to reveal shifts in microeukaryote community composition and metabolic function across depth and environmental gradients.

Zero-mode waveguide nanowells for single-molecule detection in living cells

This paper demonstrates the use of zero-mode waveguide nanowells to enable single-molecule detection in live cells by reducing observation volume and background fluorescence.

Characterization of uranyl ion binding to amyloid beta (Aβ) peptides: effects on Aβ structure and aggregation

This study investigates how uranyl ions bind to amyloid beta peptides, altering their structure and aggregation, potentially contributing to Alzheimer's disease pathology.

Diameter Dependence of Transport through Nuclear Pore Complex Mimics Studied Using Optical Nanopores

The paper studies transport selectivity through NPC mimics by measuring translocation rates of Kap95 and BSA across varying pore sizes and observes a decrease in selectivity for larger pores.

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

This study evaluates the reliability and accuracy of single-molecule FRET for measuring protein structural dynamics and distances, finding high precision and accuracy with specific uncertainty limits.

Inferring kinetic rate constants from single-molecule FRET trajectories - a blind benchmark of kinetic analysis tools

This study benchmarks eleven tools for inferring kinetic rate constants from smFRET trajectories using simulated and experimental data with varying challenges.

6-gingerol interferes with amyloid-beta (Aβ) peptide aggregation

This study shows that 6-gingerol inhibits Aβ40 peptide aggregation in vitro without interacting with monomers, suggesting it as a potential anti-Alzheimer's compound.

Lithium ions display weak interaction with amyloid-beta (Aβ) peptides and have minor effects on their aggregation

This study investigates the interaction between lithium ions and amyloid-beta peptides, finding weak interactions and minor effects on aggregation, suggesting lithium's benefits in Alzheimer's may not stem from direct peptide interactions.

Sub-millisecond conformational dynamics of the A2A adenosine receptor revealed by single-molecule FRET

This study uses smFRET to analyze the conformational dynamics of the A2A adenosine receptor, revealing slow and fast dynamics in different ligand-bound states.

Substrate binding modulates the conformational kinetics of the secondary multidrug transporter LmrP

This study uses smFRET to show substrate binding modulates conformational kinetics of LmrP, revealing substrate-dependent structural changes in MFS transporters.

Hydrophobic organic contaminants are not linked to microplastic uptake in Baltic Sea herring

This study investigates whether hydrophobic organic contaminants (HOCs) in Baltic Sea herring are linked to microplastic (MP) ingestion, finding no such relationship.

Microplastic-mediated transport of PCBs? A depuration study with Daphnia magna

This study evaluates PCB removal in Daphnia magna exposed to microplastic and algae, finding more efficient removal of PCB 209 but no overall difference in total PCB burden.

Quantitative single-molecule three-color Förster resonance energy transfer by photon distribution analysis

This paper introduces 3C-PDA, a method to analyze three-color FRET data to extract inter-dye distance distributions, revealing coordinated domain motions in biomolecules.

Dynamic interactions of type I cohesin modules fine-tune the structure of the cellulosome of Clostridium thermocellum

This study uses single-molecule techniques and simulations to show that cohesin-cohesin interactions and linker flexibility in scaffoldin proteins are critical for cellulosome structure and function.

Stability of local secondary structure determines selectivity of viral RNA chaperones

This study compares the ability of viral RNA chaperones NSP2 and σNS to promote inter-segment RNA-RNA interactions, finding that NSP2's high affinity for structured RNAs and efficient helix disruption enable successful inter-segment association, while σNS lacks this capacity.