R. Ding

Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation

This study shows SCD1 regulates FMDV replication by modulating lipid metabolism and 2C-mediated replication complex formation, suggesting it as a potential drug target for positive-sense RNA viruses.

Structural basis for CCR6 modulation by allosteric antagonists

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.

Identification of cytokine predominant immunosuppressive class and prognostic risk signatures in glioma

The paper identifies an immunosuppressive class of glioblastoma (IDC) with high anti-inflammatory cytokine expression and poor prognosis, suggesting resistance to immune checkpoint blockade therapy.

Novel MBLs inhibitors screened from FDA-approved drug library restore the susceptibility of carbapenems to NDM-1-harbouring bacteria

The paper screens FDA-approved drugs to find inhibitors of NDM-1, restoring carbapenem efficacy against resistant bacteria.

Zinc finger protein Zfp335 controls early T cell development and survival through beta-selection-dependent and -independent mechanisms

This study identifies Zfp335 as a transcription factor regulating T cell development by controlling TCRβ expression and cell survival through β-selection-dependent and -independent mechanisms.

Plasticity in stomatal behavior across a gradient of water supply is consistent among field-grown maize inbred lines with varying stomatal patterning

The study finds that stomatal conductance model parameters m and g1 are consistent across diverse maize genotypes under varying water supplies, suggesting flexibility in water use efficiency mechanisms.

The cause of on-target point mutations generated by CRISPR-Cas9 treatment in the yeast Xanthophyllomyces dendrorhous

This study identifies on-target point mutations caused by CRISPR-Cas9 in yeast, showing sequence dependence and involvement of NHEJ components.

1,25(OH)2D3 attenuates hepatic insulin resistance in rats with streptozotocin -induced diabetes via antioxidation

This study shows that 1,25(OH)2D3 reduces hepatic insulin resistance in diabetic rats by improving antioxidant status and enhancing AKT/GLUT2 expression.

Structural Insights Into the Initiation and Elongation of Ubiquitination by Ubr1

This study reports cryo-EM structures of Ubr1 complexes to elucidate the mechanism of ubiquitination initiation and elongation using a single E2 enzyme.

The expression of PDCD1 and CD274 in T cells and macrophages correlated positively with COVID-19 severity

The paper analyzes public data to show that PDCD1 and CD274 expression in T cells and macrophages correlates with COVID-19 severity.

A quasi-paired cohort strategy reveals the impaired detoxifying function of microbes in the gut of autistic children

This study identifies impaired microbial detoxification in autistic children using a quasi-paired cohort strategy, linking it to mitochondrial damage and potential therapeutic strategies.

Single-cell transcriptome analysis of the immunosuppressive effect of differential expression of tumor PD-L1 on responding TCR-T cells

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.