Author

D. M. Stevenson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:bacteria (other)· 4 Research Focus:host-pathogen & immune response· 4 Assay:metabolomics· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:gene regulatory network inference· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

D. Amador-Noguez· 8 shared J.-D. Sauer· 4 shared D. Pensinger· 2 shared H. B. Smith· 2 shared T. N. Huynh· 2 shared A. J. Hryckowian· 1 shared A. Turdiev· 1 shared B. O. Oyserman· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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8 shared papersMicrobiology

D. Amador-Noguez

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8 papers

Recent·Most cited

C-di-AMP accumulation disrupts glutathione metabolism and inhibits virulence program expression in Listeria monocytogenes

C. Siletti, M. J. Freeman, Z. Tu, D. M. Stevenson, D. Amador-Noguez, J.-D. Sauer, T. N. Huynh

This study shows that c-di-AMP accumulation in Listeria monocytogenes disrupts glutathione metabolism, leading to reduced virulence gene expression and attenuated pathogenesis.

bioRxiv · Jan 18, 2024 · PreprintMicrobiology

Exogenous butyrate inhibits butyrogenic metabolism and alters expression of virulence genes in Clostridioides difficile

D. Pensinger, H. A. Dobrila, D. M. Stevenson, N. M. Davis, D. Amador-Noguez, A. J. Hryckowian

This study shows exogenous butyrate inhibits C. difficile growth by interfering with its own butyrate production and alters virulence gene expression.

bioRxiv · Jul 6, 2023 · PreprintMicrobiology

Listeria monocytogenes requires DHNA-dependent intracellular redox homeostasis facilitated by Ndh2 for survival and virulence

H. B. Smith, K. Lee, D. M. Stevenson, D. Amador-Noguez, J.-D. Sauer

This study shows that Listeria monocytogenes uses DHNA-dependent redox homeostasis via Ndh2 for survival and virulence, independent of respiration.

bioRxiv · Jan 13, 2023 · PreprintMicrobiology

Listeria monocytogenes GlmR is an accessory uridyltransferase essential for cytosolic survival and virulence

D. Pensinger, K. V. Gutierrez, H. B. Smith, W. J. B. Vincent, D. M. Stevenson, K. A. Black, K. M. Perez-Medina, J. P. Dillard, K. Y. Rhee, D. Amador-Noguez, T. N. Huynh, J.-D. Sauer

This study identifies GlmR as an accessory uridyltransferase essential for Listeria monocytogenes cytosolic survival and virulence by synthesizing UDP-GlcNAc.

bioRxiv · Oct 27, 2021 · PreprintMicrobiology

Prostaglandin E2 induction by cytosolic Listeria monocytogenes in phagocytes is necessary for optimal T-cell priming

C. E. McDougal, Z. T. Morrow, S. Kim, D. Carter, D. M. Stevenson, D. Amador-Noguez, M. J. Miller, J.-D. Sauer

This study identifies PGE2 production via COX-2 as a cytosol-dependent innate immune response critical for CD8+ T-cell priming against L. monocytogenes.

bioRxiv · Mar 23, 2021 · PreprintImmunology

Autotrophic and mixotrophic metabolism of an anammox bacterium revealed by in vivo 13C and 2H metabolic network mapping

C. E. Lawson, G. Nuijten, R. M. de Graaf, T. B. Jacobson, M. Pabst, D. M. Stevenson, M. S. M. Jetten, D. R. Noguera, K. D. McMahon, D. Amador-Noguez, S. Lücker

This study uses isotope tracing and metabolomics to resolve the central carbon metabolism of an anammox bacterium, revealing discrepancies between genomic predictions and in vivo metabolic fluxes.

The ISME Journal · Oct 20, 2020Peer-reviewedMicrobiology

Systemic characterization of pppGpp, ppGpp and pGpp targets in Bacillus reveal NahA converts (p)ppGpp to pGpp to regulate alarmone composition and signaling

J. Yang, B. W. Anderson, A. Turdiev, H. Turdiev, D. M. Stevenson, D. Amador-Noguez, V. T. Lee, J. D. Wang

The paper identifies pGpp as a third alarmone in Bacillus and shows NahA converts (p)ppGpp to pGpp, altering alarmone composition and stress response.

bioRxiv · Mar 23, 2020 · PreprintMicrobiology

acI Actinobacteria Assemble a Functional Actinorhodopsin with Natively-synthesized Retinal

J. R. Dwulit-Smith, J. J. Hamilton, D. M. Stevenson, S. He, B. O. Oyserman, F. Moya-Flores, D. Amador-Noguez, K. McMahon, K. T. Forest

This study demonstrates that acI Actinobacteria can synthesize retinal and assemble functional actinorhodopsins for proton pumping using genomic and heterologous expression analyses.

bioRxiv · Jul 11, 2018Microbiology