Rescue of proteotoxic stress and neurodegeneration by the Zn2+ transporter ZIP7
X. GUO, M. Mutch, A. Y. Torres, M. Nano, D. McDonald, Z. Chen, C. Montell, W. Dai, D. Montell
This study shows ZIP7 enhances ERAD by supplying cytosolic Zn2+ for Rpn11 deubiquitination, rescuing vision loss in Drosophila with misfolded rhodopsin.
bioRxiv · May 22, 2023 · PreprintCell Biology