Helical remodeling augments 5-lipoxygenase activity
E. M. Gallegos, T. D. Reed, F. A. Mathes, N. Guevara, D. Neau, W. Huang, M. E. Newcomer, N. C. Gilbert
This study shows that helical remodeling of 5-LOX enhances its activity by enabling substrate access and improving kinetic parameters.
bioRxiv · Mar 31, 2022 · PreprintBiochemistry