W. Gao

SARS-CoV-2 B Epitope-Guided Neoantigen NanoVaccines Enhance Tumor-Specific CD4/CD8 T Cell Immunity Through B Cell Antigen Presentation

This study develops a neoantigen vaccine using SARS-CoV-2 B cell epitopes to enhance CD4/CD8 T cell immunity through B cell antigen presentation, showing improved efficacy in multiple cancer models.

AI-driven high-throughput droplet screening of cell-free gene expression

This paper introduces DropAI, an AI-driven droplet-based screening method to optimize cell-free gene expression systems, achieving cost reduction and yield improvement.

Informing grassland ecosystem modeling with in-situ and remote sensing observations

This paper improves grassland productivity modeling by integrating field data and satellite observations with the DayCent-UV model, showing strong agreement with both remote sensing and local measurements.

Molecular Mechanism of Huanglian Jiedu Decoction in Treatment of Alzheimer's Disease based on Network Pharmacology

This study uses network pharmacology to identify the molecular mechanism of Huanglian Jiedu Decoction in treating Alzheimer's disease, revealing its anti-inflammatory effects through multiple targets and pathways.

14-3-3 binding motif phosphorylation disrupts Hdac4 organized condensates to stimulate cardiacreprogramming

This study identifies a phosphorylation code in 14-3-3 binding motifs that stimulates induced cardiomyocyte formation by disrupting Hdac4 condensates.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

The polyamine transporter ATP13A3 mediates DFMO-induced polyamine uptake in neuroblastoma

This study identifies ATP13A3 as a polyamine transporter mediating DFMO-induced polyamine uptake in neuroblastoma, highlighting it as a therapeutic target.

Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy

This paper develops a dual-targeting compound that eliminates regulatory B cells and overcomes STING resistance in pancreatic cancer, improving immunotherapy outcomes.

Transient BRD4 degradation improves cardiac reprogramming by inhibiting macrophage/Oncostatin M induced JAK/STAT pathway

This study identifies BRD4 degradation as a method to enhance cardiac reprogramming by inhibiting the JAK/STAT pathway activated by macrophages and oncostatin M.

Host signature as major driver of root and rhizosphere core microbiomes that differently affect plant functional traits

The paper identifies plant traits as the main driver of core microbiomes in different root compartments and shows their distinct impacts on plant metal accumulation and growth.

Presence of NCOR1+/CD4+ T cells in tertiary lymphoid organ predicts favorable prognosis in pancreatic ductal adenocarcinoma

The paper shows that NCOR1+/CD4+ T cells in tertiary lymphoid organs predict better outcomes in pancreatic ductal adenocarcinoma patients.

Collagen Tubular Airway-on-Chip for Extended Epithelial Culture andInvestigation of Ventilation Dynamics

This paper introduces a collagen tube-based airway-on-chip model that supports two-week epithelial culture and studies ventilation dynamics under physiological conditions.

Chemical proteomic approach for in-depth glycosylation profiling of plasma carcinoembryonic antigen in cancer patients

This paper develops a chemical proteomic method to profile site-specific glycosylation of low-abundance plasma CEA in cancer patients, revealing differential glycoforms associated with cancer types and progression stages.

MolPhase: An Advanced Phase Separation Predictor and an Investigation of Phytobacterial Effector in Plant

MolPhase predicts protein phase separation using physicochemical features and experimental data, showing T3Es undergo homotypic phase separation in vitro and in vivo.

Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer

The paper identifies host-microbiota interactions in colorectal cancer subtypes, revealing distinct gene-microbe associations that contribute to tumor microenvironment heterogeneity.

Metabolic capabilities are highly conserved among human nasal-associated Corynebacterium species in pangenomic analyses

The paper analyzes the metabolic capabilities of four common human nasal Corynebacterium species using pangenomic data, finding high conservation of core metabolic functions across species and geographic strains.

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2

This study reports cryo-EM structures of HCAR2-Gi1 complexes with agonists, revealing ligand recognition, selectivity, and activation mechanisms for drug design.

Multimodal meta-analysis of fecal metagenomes reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer

This study identifies microbial single nucleotide variants (SNVs) as superior biomarkers for early detection of colorectal cancer, outperforming species-level signatures in multiple validation cohorts.

Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

This paper develops engineered retrovirus-like nanocarriers for efficient mRNA delivery into neurons by modifying extracellular vesicles with Arc protein capsids and RNA elements.

Guiding Irregular Nuclear Morphology on Nanopillar Array for Malignancy Differentiation in Tumor cells

This paper uses nanopillar arrays to quantify subnuclear morphology in tumor cells, showing it correlates with malignancy and drug response.

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

Dual-lipid metabolomics revealed the communication of MTB or MB with Bovine alveolar macrophages in lipid metabolisms

This study uses dual-lipid metabolomics to compare lipid compositions of MTB and MB and their effects on bovine alveolar macrophages, revealing distinct metabolic responses and colonization mechanisms.

Diversity of Treponema denticola and other oral treponeme lineages in subjects with periodontitis and gingivitis

The paper compares the diversity of Treponema denticola and other oral treponeme lineages in periodontitis and gingivitis patients using pyrH gene sequencing.

Genomic Stability and Genetic Defense Systems in Dolosigranulum pigrum a Candidate Beneficial Bacterium from the Human Microbiome

This study analyzes the genomic stability and defense mechanisms of Dolosigranulum pigrum, a beneficial human nasal bacterium, using 28 genomes to reveal its chromosomal structure, MGEs, and defense systems.

Unbalanced dietary patterns contribute to the pathogenesis of precocious puberty by affecting gut microbiota and host metabolites

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

Resuscitation of soil microbiota after > 70-years of desiccation

This study assesses bacterial abundance and diversity in 70-year-old desiccated soils, showing significant resuscitation potential and activity of certain taxa after rewetting.

Comparative study of curvature sensing mediated by F-BAR domain and an intrinsically disordered region of FBP17

This study shows that the intrinsically disordered region of FBP17, not its F-BAR domain, is responsible for curvature sensing in membrane dynamics.

Enabling in vivo Analysis Via Nanoparticle-mediated Intracellular Assay Probe Delivery: Using RAS as the Prototype

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

A novel biparatopic antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody libraries