Author

D. Offen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Prakash· 1 shared C. J. Ramachandra· 1 shared D. J. Hausenloy· 1 shared E. P. Yap· 1 shared F. Benninger· 1 shared F. Yu· 1 shared G. E. Crespo-Avilan· 1 shared J. Ching· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperPhysiology

A. Prakash

Mutual co-authors in cluster

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2 papers

Recent·Most cited

The DJ-1-derived peptide, ND-13, confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathway

A. Prakash, G. E. Crespo-Avilan, S. J. Loo, E. P. Yap, J. Chua, J. Ching, Z. Yitong, Y.-H. Lin, W. Contreras, F. Yu, S. Cong, L. C. Dam, C. J. Ramachandra, S. B. Kalkhoran, S. Lu, , D. J. Hausenloy

This study shows that the DJ-1-derived peptide ND-13 reduces myocardial infarct size and preserves cardiac function by inhibiting mitochondrial fission and improving mitochondrial bioenergetics through the RhoA-ROCK1-Drp1 pathway.

bioRxiv · Jun 24, 2024 · PreprintPhysiology

Computationally Engineered CRISPR-SpyCas9 High-Fidelity Variants with Improved Specificity and Reduced Non-specific DNA Damage

R. Rabinowitz, O. Shor, J. Zerbib, S. Herman, N. Zelikson, S. Madiwale, N. Yom-Tov, U. Ben-David, F. Benninger, D. Offen

The paper develops ComPE, a computational method to engineer high-fidelity CRISPR-Cas9 variants with improved specificity and reduced off-target effects.

bioRxiv · Apr 11, 2023 · PreprintBioengineering