F. Yu

Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

The DJ-1-derived peptide, ND-13, confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathway

This study shows that the DJ-1-derived peptide ND-13 reduces myocardial infarct size and preserves cardiac function by inhibiting mitochondrial fission and improving mitochondrial bioenergetics through the RhoA-ROCK1-Drp1 pathway.

Clinical factors associated with SFTS diagnosis and severity in cats

This study identifies clinical biomarkers and develops a scoring model to predict SFTSV infection in cats, while analyzing the relationship between viral strain and disease severity.

PHOSPHATE-INDUCED 1 and its paralogs positively regulate cellulose biosynthesis in Arabidopsis.

This study shows that PHOSPHATE-INDUCED 1 and its paralogs regulate cellulose biosynthesis in Arabidopsis by modulating CSC activity in response to developmental and environmental cues.

A Dimerization-dependent Allosteric Activation for Receptor-like Kinase in Plants

The paper shows that FERONIA (FER) activates its homologs through dimerization-dependent allosteric activation, with ROS enhancing dimerization and impacting plant responses like ABA-mediated stomatal movement.

Architecture of Ca2+ tunneling, a basic Ca2+ signaling modality important for secretion

This study outlines the architecture of Ca2+ tunneling, a Ca2+ signaling modality, and shows it is important for Cl- secretion in sweat glands.

Armillaria korhonenii, the sixteenth biological species of Armillaria from China

The paper describes a new species of Armillaria, Armillaria korhonenii, based on phylogenetic, morphological, and mating test evidence, identifying it as the sixteenth biological species in China.

Regulated Cleavage and Relocation of FERONIA Control Immunity in Arabidopsis Roots

Bacteria induce FER cleavage via At2-MMP to trigger localized immunity in Arabidopsis root transition/elongation zones.

Multi-omic stratification of the missense variant cysteinome

This paper uses chemoproteogenomics to identify gain-of-cysteine variants in cancer and healthy genomes, revealing their prevalence and potential for drug targeting.

Helicity of a tardigrade disordered protein promotes desiccation tolerance

This study shows that helical structure in a tardigrade IDP is necessary for desiccation tolerance, but not sufficient on its own.

Labile assembly of a tardigrade protein induces biostasis

This study identifies a mechanism by which tardigrade CAHS D proteins form gels to protect cells during desiccation, showing that gelation reduces molecular motion and metabolic activity, with reversible effects.

ER-Mitochondria Contact Sites expand during mitosis

The paper shows that ER-mitochondria contact sites expand during mitosis, enhancing Ca2+ coupling and mitochondrial activation to meet increased energy demands.

Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis

This paper develops an MMP13-targeting siRNA conjugate that preferentially accumulates in arthritic joints, reducing disease markers and outperforming current treatments.

The soil emergence-related transcription factor PIF3 regulates root penetration by interacting with the receptor kinase FER

This study shows that PIF3, a transcription factor, regulates root penetration in Arabidopsis by interacting with FER, a receptor kinase, and modulating mechanosensitive ion channels and root cap cell sloughing.

Structural preferences shape the entropic force of disordered protein ensembles

The paper uses all-atom simulations to show that sequence-encoded structural preferences in disordered protein regions influence the magnitude of entropic forces generated upon tethering.

Androgen-mediated TGFβ expression suppresses anti-tumor neutrophil response in bone metastatic prostate cancer

This study identifies androgen-mediated TGFβ expression as a mechanism suppressing anti-tumor neutrophil response in bone metastatic prostate cancer and shows that combining ADT with TGFβ receptor inhibition restores neutrophil cytotoxicity.

Large-scale analysis of the N-terminal regulatory elements of the kinase domain in plant receptor-like kinase family

The paper analyzes NRE sequences in RLKs and RLCKs from 528 plants to uncover structural-functional relationships and phosphorylation motifs, revealing their role in kinase regulation.

HLA-Glyco: A large-scale interrogation of the glycosylated immunopeptidome

The paper develops a computational workflow for glyco-immunopeptidomics, identifies glycosylated MHC class II peptides, and provides a resource with over 3,400 HLA class II N-glycopeptides.

cpSRP54 and FtsH cooperate thylakoid membrane associated proteostasis during de-etiolation in Arabidopsis thaliana

The paper shows cpSRP54 and FtsH work together in thylakoid membrane protein quality control during de-etiolation in Arabidopsis, and provides a trackable marker for monitoring their activities.

STIM1 signals through NFAT independently of Orai1 and SOCE to regulate breast cancer cell migration

The paper shows that STIM1 knockout in breast cancer cells increases migration and invasion due to NFATC2 downregulation, independent of SOCE and Ca2+ entry.

Expression of Microcystis biosynthetic gene clusters in natural populations suggests temporally dynamic synthesis of novel and known secondary metabolites in western Lake Erie

The paper analyzes Microcystis BGCs in western Lake Erie cyanoHABs to show dynamic expression of known and novel secondary metabolites linked to environmental factors.

Wounding promotes root regeneration through a cell wall integrity sensor, the receptor kinase FERONIA

The paper identifies RALF33-FER as an early signaling module between wounding and root regeneration, interacting with TPL/TPRs to regulate regeneration-related genes.

Ploidy variation and spontaneous haploid-diploid switching of Candida glabrata clinical isolates

This study reports ploidy variation and spontaneous haploid-diploid switching in 500 clinical Candida glabrata isolates, revealing differences in morphology, antifungal susceptibility, virulence, and gene expression.

Glycopeptide antibiotic teicoplanin inhibits cell entry of SARS-CoV-2 by suppressing the proteolytic activity of cathepsin L

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

PanGu Drug Model: Learn a Molecule Like a Human

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

The Structural and Biochemical Basis for FER Receptor Kinase Early Signaling Initiation in Arabidopsis

This study investigates the structural and biochemical basis of early FER receptor kinase signaling in Arabidopsis, revealing an active conformation and the role of Tyr phosphorylation in substrate activation.

Plant Virus Database: a resource for exploring the diversity of plant viruses and their interactions with hosts

The paper builds a comprehensive Plant Virus Database (PVD) containing 3,206 virus species and 9,604 host interactions, revealing significant virome differences between plant groups and regions.

The Receptor Kinase FER Mediates Phase Separation of Glycine-Rich RNA-Binding Protein 7 to Confer Temperature Resilience in Arabidopsis

This study shows that FER-mediated phosphorylation of GRP7 promotes phase separation, enhancing Arabidopsis temperature resilience by forming stress granules that inhibit translation during temperature shifts.

Cell surface receptor kinase FERONIA linked to nutrient sensor TORC signaling controls root hair growth at low temperature linked to low nitrate in Arabidopsis thaliana

The paper identifies a molecular mechanism involving FER, ROP2, and TORC that controls root hair elongation under low temperature and nitrogen deficiency in Arabidopsis thaliana.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.