Cancer BiologybioRxiv
Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs
M. Gilardi, R. Saddawi-Konefka, V. H. Wu…·J. S. Gutkind
This study demonstrates that microneedle-mediated local delivery of anti-CTLA-4 antibody reduces immune-related adverse events while effectively treating oral squamous cell carcinoma.
DOI 10.1158/1535-7163.mct-21-0234