Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
V. T. K. Le-Trilling, S. Banchenko, D. Paydar, P. M. Leipe, L. Binting, S. Lauer, A. Graziadei, C. Gotthold, J. Burger, T. Bracht, B. Sitek, R. J. Lebbink, A. Malyshkina, T. Mielke, J. Rappsilber, , D. Schwefel
This study identifies E27 as a viral protein that targets STAT2 for degradation via CRL4 ubiquitin ligases, revealing its structural mechanism of interferon antagonism.
bioRxiv · May 5, 2022Biochemistry