The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T-cell recognition by targeting CIITA
F. Maassen, V. T. K. Le-Trilling, L. Betke…·M. Trilling
This study identifies pUS28 as a viral protein that inhibits CIITA-driven HLA-II expression, thereby blocking CD4+ T-cell recognition of HCMV-infected cells.