Author

M. Vias

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. D. Brenton· 5 shared D.-L. Couturier· 4 shared K. Hosking· 4 shared C. M. Sauer· 3 shared D. Sanders· 3 shared F. Correia Martins· 3 shared M. Jimenez-Linan· 3 shared A. M. Piskorz· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersCancer Biology

J. D. Brenton

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5 papers

Recent·Most cited

Predicting response to cytotoxic chemotherapy

J. Thompson, L. Madrid, B. Hernando, C. Sauer, M. Vias, M. Escobar-Rey, W.-K. Leung, J. Huckstep, M. Sekowska, K. Hosking, M. Jimenez-Linan, M. Reinius, H. Dobson, D. De Silva, A. Fernandez-Sanroman, , G. Macintyre

This study develops three precision biomarkers based on chromosomal instability signatures to predict response to different chemotherapies, showing improved progression-free survival in clinical trials.

bioRxiv · Jan 28, 2023Cancer Biology

Molecular landscape and functional characterization of centrosome amplification in ovarian cancer

C. M. Sauer, J. A. Hall, D.-L. Couturier, T. Bradley, A. M. Piskorz, J. Griffiths, A. Sawle, M. D. Eldridge, P. Smith, K. Hosking, M. A. Reinius, L. Morrill Gavarro, A.-M. Mes-Masson, D. Ennis, D. Millan, , J. D. Brenton

This study identifies centrosome amplification as a common and heterogeneous feature in HGSOC, linked to CIN and treatment resistance.

bioRxiv · Sep 13, 2022Cancer Biology

High-grade serous ovarian carcinoma organoids as models of chromosomal instability

M. Vias, L. Morrill Gavarro, C. M. Sauer, D. Sanders, A. M. Piskorz, D.-L. Couturier, S. Ballereau, B. Hernando, J. Hall, F. Correia-Martins, F. Markowetz, G. Macintyre, J. D. Brenton

This study develops HGSOC patient-derived organoids to model chromosomal instability and its mutational processes, showing they represent different causes of instability and can be used for drug sensitivity testing.

bioRxiv · Sep 1, 2022Cancer Biology

Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models

C. M. Sauer, K. Heider, J. Belic, S. E. Boyle, J. A. Hall, D.-L. Couturier, A. An, A. Vijayaraghavan, M. A. Reinius, K. Hosking, M. Vias, N. Rosenfeld, J. D. Brenton

This study develops a method to monitor ctDNA in PDX mice using dried blood spots, enabling longitudinal tracking of disease burden and treatment response.

bioRxiv · Jan 15, 2022Cancer Biology

Somatic chromosomal number alterations affecting driver genes inform in-vitro and clinical drug response in high-grade serous ovarian cancer

F. Correia Martins, D.-L. Couturier, I. Santiago, C. Sauer, M. Vias, M. Angelova, D. Sanders, A. Piskorz, J. Hall, K. Hosking, A. Amirthanayagam, S. Cosulich, L. Carnevalli, B. Davies, T. B. K. Watkins, , J. D. Brenton

This study shows that somatic copy number alterations in driver genes correlate with drug response in HGSOC spheroid models and clinical settings.

bioRxiv · Oct 4, 2020 · PreprintCancer Biology