Author

M. Jimenez-Linan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:whole-genome sequencing· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. D. Brenton· 4 shared F. Correia Martins· 3 shared K. Hosking· 3 shared M. Vias· 3 shared A. Hoyle· 2 shared A. M. Piskorz· 2 shared A. Piskorz· 2 shared C. Sauer· 2 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCancer Biology

J. D. Brenton

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5 papers

Recent·Most cited

Predicting response to cytotoxic chemotherapy

J. Thompson, L. Madrid, B. Hernando, C. Sauer, M. Vias, M. Escobar-Rey, W.-K. Leung, J. Huckstep, M. Sekowska, K. Hosking, M. Jimenez-Linan, M. Reinius, H. Dobson, D. De Silva, A. Fernandez-Sanroman, , G. Macintyre

This study develops three precision biomarkers based on chromosomal instability signatures to predict response to different chemotherapies, showing improved progression-free survival in clinical trials.

bioRxiv · Jan 28, 2023Cancer Biology

Molecular landscape and functional characterization of centrosome amplification in ovarian cancer

C. M. Sauer, J. A. Hall, D.-L. Couturier, T. Bradley, A. M. Piskorz, J. Griffiths, A. Sawle, M. D. Eldridge, P. Smith, K. Hosking, M. A. Reinius, L. Morrill Gavarro, A.-M. Mes-Masson, D. Ennis, D. Millan, , J. D. Brenton

This study identifies centrosome amplification as a common and heterogeneous feature in HGSOC, linked to CIN and treatment resistance.

bioRxiv · Sep 13, 2022Cancer Biology

Somatic chromosomal number alterations affecting driver genes inform in-vitro and clinical drug response in high-grade serous ovarian cancer

F. Correia Martins, D.-L. Couturier, I. Santiago, C. Sauer, M. Vias, M. Angelova, D. Sanders, A. Piskorz, J. Hall, K. Hosking, A. Amirthanayagam, S. Cosulich, L. Carnevalli, B. Davies, T. B. K. Watkins, , J. D. Brenton

This study shows that somatic copy number alterations in driver genes correlate with drug response in HGSOC spheroid models and clinical settings.

bioRxiv · Oct 4, 2020 · PreprintCancer Biology

The mutational landscape of normal human endometrial epithelium

L. Moore, D. Leongamornlert, T. H. Coorens, M. A. Sanders, P. Ellis, K. Dawson, F. Maura, J. Nangalia, P. S. Tarpey, S. F. Brunner, H. Lee-Six, R. Rahbari, S. Moody, Y. Hooks, K. Mahbubani, , M. R. Stratton

This study characterizes the mutational landscape of normal human endometrial epithelium, revealing age-related mutation burdens and driver mutations in cancer genes.

bioRxiv · Dec 24, 2018Cancer Biology

Copy-number signatures and mutational processes in ovarian carcinoma

G. Macintyre, T. Goranova, D. De Silva, D. Ennis, A. M. Piskorz, M. Eldridge, D. Sie, L.-A. Lewsley, A. Hanif, C. Wilson, S. Dowson, R. M. Glasspool, M. Lockley, E. Brockbank, A. Montes, , J. D. Brenton

This study identifies copy-number signatures in ovarian cancer and links them to mutational processes, showing that most cases involve multiple processes, suggesting therapeutic challenges.

bioRxiv · Sep 4, 2017Cancer Biology