The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome.
C. Stanton, C. Buasakdi, J. Sun, I. Levitan, P. Bora, S. Kutseikin, L. Wiseman, M. Bollong
This study shows methylglyoxal, a glycolytic metabolite, covalently inactivates the NLRP3 inflammasome by forming crosslinks, thereby reducing inflammation.
bioRxiv · Apr 19, 2024Cell Biology