Author

D. Sarnello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Dawson· 1 shared A. Fassati· 1 shared A. Ianniciello· 1 shared A. Vazquez· 1 shared A. Zhyvoloup· 1 shared D. Chatterjee· 1 shared D. Planas· 1 shared D. Sumpton· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Dawson

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2 papers

Recent·Most cited

Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing

M. M. Zarou, K. M. Rattigan, D. Sarnello, A. Dawson, A. Ianniciello, K. Dunn, M. Copland, D. Sumpton, A. Vazquez, V. Helgason

The paper shows that inhibiting mitochondrial folate metabolism drives differentiation in CML cells via mTORC1 and purine sensing, and enhances the efficacy of imatinib in reducing therapy-resistant LSCs.

bioRxiv · Dec 21, 2022 · PreprintCancer Biology

Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

T. R. Wiche Salinas, Y. Zhang, D. Sarnello, A. Zhyvoloup, L. Raymond-Marchand, D. Planas, M. Lodha, D. Chatterjee, K. Karwacz, S. Oxenford, J.-P. Routy, H. Amrine-Madsen, P. Ancuta, A. Fassati

This paper identifies RORC2 as a key host factor that promotes HIV-1 gene expression and viral outgrowth in Th17 cells, suggesting it as a new therapeutic target.

bioRxiv · Mar 27, 2021Microbiology