A. Dawson

Bacterial aggregation triggered by low-level antibiotic-mediated lysis

This study shows low-dose antibiotics trigger bacterial aggregation via lysis and extracellular DNA release, forming aggregates distinct from biofilms.

Metabolic reprogramming provides a novel approach to overcome resistance to BH3-mimetics in Malignant Pleural Mesothelioma

This study identifies metabolic reprogramming as a strategy to overcome resistance to BH3-mimetics in MPM by combining glycolytic inhibition with MCL-1 and BCL-2/BCL-XL targeting.

Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing

The paper shows that inhibiting mitochondrial folate metabolism drives differentiation in CML cells via mTORC1 and purine sensing, and enhances the efficacy of imatinib in reducing therapy-resistant LSCs.

Heavy metal pollution impacts soil bacterial community structure and antimicrobial resistance at the Birmingham 35th Avenue Superfund Site

This study examines how heavy metal pollution affects soil bacterial communities and antimicrobial resistance at a Superfund site, finding reduced diversity and increased AMR gene prevalence in contaminated soils.

Predictable and stable epimutations induced during clonal propagation with embryonic transcription factors

The paper investigates how epigenetic modifications during clonal propagation affect phenotypic variation in Arabidopsis thaliana, showing that tissue-specific DNA methylation imprints drive these changes.

Efficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma

This study evaluates CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma, finding they reduce tumor growth and improve survival by inducing cell cycle arrest and senescence.

A transposon surveillance mechanism that safeguards plant male fertility during stress

This study identifies two Argonaute-like proteins essential for maintaining male fertility in maize under high temperatures by controlling retrotransposon activity.

Multiomics Characterization of Potential Therapeutic Vulnerabilities in Low-grade Serous Ovarian Carcinoma

This study uses multiomics analysis of LGSOC cell lines to identify therapeutic vulnerabilities and biomarkers for MEK inhibitor efficacy.

Towards understanding predictability in ecology: A forest gap model case study

This paper evaluates uncertainty components in forest gap model predictions using a data assimilation algorithm, finding that process uncertainty dominates over demographic and initial condition uncertainties.

Stability of β-lactam antibiotics in bacterial growth media

This study measures the degradation half-lives of β-lactam antibiotics in bacterial growth media and highlights potential issues with interpreting MIC tests due to antibiotic instability.

A new role for histone demethylases in the maintenance of plant genome integrity

This study identifies ELF6 and REF6 as JMJ histone demethylases in Arabidopsis that maintain H3K27me3 and H3K27me1 homeostasis, preventing epigenetic imprints and transposon activation during sexual reproduction.

Statistically-estimated tree biomass, stem density, and basal area for the upper Midwestern United States at the time of Euro-American settlement

The paper estimates tree biomass, stem density, and basal area in the upper Midwestern US at Euro-American settlement using PLS data and statistical smoothing.