Peripheral sgp130-mediated trans-signaling blockade induces obesity and insulin resistance in mice via PPARα suppression
T. Lanton, O. Levkovitch-Siany, S. Udi, J. Tam, R. Abramovich, S. Perles, E. Williams, J. Rachmilewitz, U. Mor, E. Elinav, D. Schmidt-Arras, A. Rehman, P. Rosenstiel, A. Giannou, S. Huber, , J. H. Axelrod
This study shows that blocking peripheral sgp130-mediated trans-signaling in mice causes obesity and insulin resistance by suppressing PPARα.
bioRxiv · Sep 24, 2020 · PreprintPhysiology